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Scientists to debate the newest most cancers therapies, advances in PSMA PET scans and plenty of extra at ASCO



Physicians and scientists from the UCLA Jonsson Complete Most cancers Heart will talk about the newest analysis and scientific trial outcomes on mixture therapies for breast most cancers, a possible new therapy for sufferers with recurrent glioma, and advances in PSMA PET guided radiotherapy for sufferers with prostate most cancers, amongst different matters, on the American Society of Medical Oncology’s annual assembly.

At this yr’s scientific discussion board, Dr. Dennis Slamon, chair of hematology-oncology and director of scientific and translational analysis on the UCLA Jonsson Complete Most cancers Heart, will current findings from the NATALEE scientific trial (summary LBA500), which seems at including ribociclib, a focused remedy drug, to straightforward hormone remedy as adjuvant therapy for sufferers with early hormone-receptor constructive/HER2 adverse breast most cancers. The outcomes will likely be highlighted through the oral presentation on June 2 at 2:45pm CT in Corridor D1.

Dr. Timothy Cloughesy, professor of neuro-oncology on the David Geffen Faculty of Drugs at UCLA, is the senior creator of summary LBA1, which highlights INDIGO scientific trial outcomes, a world, randomized double-blinded, part 3 examine of vorasidenib verse placebo in sufferers with residual or recurrent grade 2 glioma with an IDH1/2 mutation. The findings will likely be introduced through the plenary session on June 4 at 1PM CT in Corridor B1.

On this time of exceptional and speedy development in most cancers medication, the info and experiences introduced throughout these periods at ASCO provide necessary insights into rising areas of examine, and permit a vital open discussion board for participation with a variety of high specialists.”


Dr. Michael Teitell, Director, UCLA Jonsson Complete Most cancers Heart

Highlights of noteworthy displays at ASCO 2023 that function contributions from UCLA researchers embody (all instances are listed in CDT):

Breast most cancers

Oral summary session

Part III NATALEE trial of ribociclib + endocrine remedy as adjuvant therapy in sufferers with HR+/HER2− early breast most cancers.

Summary: LBA500

Presenter: Dennis Slamon, MD, PhD

Date: June 2 at 2:45PM

Location: Corridor D1

Poster periods

A part 3 examine of gedatolisib plus fulvestrant with and with out palbociclib in sufferers with HR+/ HER2- superior breast most cancers beforehand handled with a CDK4/6 inhibitor plus a nonsteroidal aromatase inhibitor (VIKTORIA-1).

Summary: TPS1118 | Poster Bd #: 335b

Presenter: Sara A. Hurvitz, MD, FACP

Date: June 4 from 8 to 11AM.

Location: Corridor A

UCLA B-13: A part 1b trial evaluating the protection of ribociclib, tucatinib, and trastuzumab in sufferers with metastatic, HER2+ breast most cancers and a multicenter, randomized, open-label, part 2 examine of preoperative therapy with ribociclib, trastuzumab, tucatinib, with or with out fulvestrant versus docetaxel, carboplatin, trastuzumab, and pertuzumab in HR+/HR-, HER2+ breast most cancers.

Summary: TPS1116 | Poster Bd #: 334b

Presenter: Nicholas Patrick McAndrew, MD, MSCE

Date: June 4 from 8 to 11AM.

Location: Corridor A

A part 1, first-in-human, open label, escalation and enlargement examine of ORM-5029, a extremely potent GSPT1 degrader focusing on HER2, in sufferers with HER2-expressing superior stable tumors.

Summary: TPS1114 | Poster Bd #: 333b

Presenter: Sara A. Hurvitz MD, FACP

Date: June 4 from 8 to 11AM.

Location: Corridor A

Mind tumors

Plenary session

INDIGO: A world, randomized, double-blinded, part 3 examine of vorasidenib versus placebo in sufferers with residual or recurrent grade 2 glioma with an IDH1/2 mutation.

Summary: LBA1

Senior Creator: Timothy Cloughesy, MD

Date: June 4 at 1PM

Location: Corridor B1.

Poster session

Depth of radiographic response (DpR) and time to tumor regrowth (TTG) to foretell general survival following anti-VEGF remedy in recurrent glioblastoma.

Summary: 2063 | Poster Bd #: 420

Presenter: Benjamin M. Ellingson, PhD

Date: June 3 from 1:15 to 4:15PM

Location: Corridor A

Prostate most cancers

Poster dialogue periods

PSMA PET guided salvage radiotherapy amongst sufferers with prostate most cancers within the post-prostatectomy setting: A single heart post-hoc evaluation.

Summary: 5009 | Poster Bd #: 103

Presenter: Jeremie Calais, MD, MSc

Date: June 3 from 1:15 to 2:45PM

Location: E450

Do bone scans over-stage illness in comparison with PSMA PET? A global multicenter retrospective examine with blinded impartial readers.

Summary: 5011 | Poster Bd #: 105

Presenter: Wolfgang Peter Fendler, MD

Date: June 3 from 1:15 to 2:45PM

Location: E40

Poster periods

Early findings from the GARUDA trial: The affect of a genetic signature of late radiation toxicity on prostate most cancers therapy resolution making.

Summary: 5089 | Poster Bd #: 183

Presenter: Joanne B. Weidhaas, MD, PhD

Date: June 3 from 8 to 11AM

Location: Corridor A

PSMA PET findings in an “EMBARK-like” cohort of sufferers with high-risk non-metastatic hormone-sensitive prostate most cancers: A single heart post-hoc retrospective evaluation.

Summary: 5091 | Poster Bd #: 185

Presenter: Wesley Robert Armstrong, BS

Date: June 3 from 8 to 11AM

Location: Corridor A

Genomic alterations and self-reported Agent Orange publicity in United States veterans with metastatic prostate most cancers.

Summary: 5068 | Poster Bd #: 162

Presenter: JJ Haijing Zhang, MD

Date: June 3 from 8 to 11AM

Location: Corridor A

Blood most cancers

Poster session

UCHMC 1812: A part 1b trial of CPX-351 plus gemtuzumab ozogamicin for relapsed/refractory acute myeloid leukemia.

Summary: 7024 | Poster Bd #: 154

Presenter: Sunmin Park, MD, PhD

Date: June 5 from 8 to 11AM

Location: Corridor A

Colorectal most cancers

Poster session

STELLAR-303: A part 3 examine of XL092 together with atezolizumab versus regorafenib in sufferers with beforehand handled metastatic colorectal most cancers.

Summary: TPS3630 | Poster Bd #: 327a

Presenter: J. Randolph Hecht, MD

Date: June 5 from 8 to 11AM

Location: Corridor A

Kidney most cancers

Poster session

Zr-DFO-girentuximab for PET/CT imaging of clear cell renal cell carcinoma: Outcomes from part 3 ZIRCON examine.

Summary: 4554 | Poster Bd #: 46

Presenter: Brian M. Shuch, MD

Date: June 3 from 8 to 11AM

Location: Corridor A

Ovarian most cancers

Poster session

Preliminary outcomes of dose discovering in a first-in-human part 1 examine of a novel Claudin 6 (CLDN6) focused antibody drug conjugate (ADC) TORL-1-23 in sufferers with superior stable tumors.

Summary: 3082 | Poster Bd #: 280

Presenter: Gottfried E. Konecny, MD

Date: June 3 from 8 to 11AM

Location: Corridor A

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