Consuming fatty fish decreased the lipophilic index in individuals with impaired glucose metabolism or coronary coronary heart illness, based on a brand new research from the College of Jap Finland. The lipophilic index is taken into account a marker of cell membrane fluidity, and a low lipophilic index signifies higher membrane fluidity. In a current research printed in Vitamin, Metabolism & Cardiovascular Illnesses, a low lipophilic index was additional related to bigger imply HDL particle dimension and better focus of enormous HDL particles, which suggests cardiovascular profit.
The lipophilic index has been launched to explain membrane fluidity, which may modify the operate of cells and membrane-bound proteins. The size and saturation of fatty acids in membranes impacts membrane fluidity. For instance, fatty acids in serum lipids or erythrocyte membranes can be utilized to calculate the lipophilic index. Earlier research have urged that long-chain omega-3 fatty acids in fish have a useful impact on cardiovascular danger, nevertheless, extra analysis into the mechanisms remains to be wanted. Camelina oil, however, is wealthy in alpha-linolenic acid, which is a necessary omega-3 fatty acid whose associations with membrane fluidity usually are not recognized.
The researchers used information from two randomized scientific trials to check the results of fish and camelina sativa oil consumption on the lipophilic index. The primary research included 79 women and men with impaired glucose tolerance. The second research included 33 women and men with heart problems. Research contributors have been randomly divided into 4 teams for a 12-week intervention: the camelina oil group, the fatty fish group, the lean fish group, and the management group within the first research. Within the second research, topics have been randomly divided into the fatty fish, lean fish, and management teams for an 8-week intervention. The lipophilic index was calculated primarily based on erythrocyte membrane fatty acids within the first research, and serum phospholipid fatty acids within the second research.
In each research, consuming 4 meals of fatty fish per week diminished the lipophilic index, which signifies higher membrane fluidity. Higher membrane fluidity has been related to decrease cardiovascular danger. Higher membrane fluidity as measured by the lipophilic index was additionally related to bigger HDL particles, which have additionally been related to a decrease cardiovascular danger. Consuming lean fish or camelina sativa oil didn’t have an effect on the lipophilic index.
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Journal reference:
Lyytinen, A. T., et al. (2023) Fatty fish consumption reduces lipophilic index in erythrocyte membranes and serum phospholipids. Vitamin, Metabolism & Cardiovascular Illnesses. doi.org/10.1016/j.numecd.2023.04.011.
