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Cymbalta Alternate options to Contemplate — Talkspace


Printed on: 30 Nov 2023

Alternatives to Cymbalta

Cymbalta (duloxetine) is a typical antidepressant for treating despair and anxiousness. It’s additionally typically prescribed for diabetic peripheral neuropathy and different medical circumstances that trigger ache, like arthritis, fibromyalgia, and power again ache. Cymbalta is in a category of medicine often known as serotonin-norepinephrine reuptake inhibitors (SNRIs). SNRIs steadiness norepinephrine and serotonin ranges — neurotransmitters related to temper regulation and application — within the mind.

Whereas Cymbalta will be very efficient for some individuals, it’s not at all times the proper treatment for everybody. It’d trigger undesirable Cymbalta unintended effects, antagonistic drug interactions, not be efficient in relieving signs, otherwise you would possibly simply be on the lookout for pure alternate options to Cymbalta use. Holistic remedy choices have gotten extra interesting and acquainted, whether or not mixed with treatment or remedy or when used independently. 

No matter your cause is for wanting into Cymbalta alternate options, we’re diving into every part you’ll want to learn about pure cures and different medicine just like Cymbalta. 

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Various Medicines to Cymbalta

There are a number of medicines that could be viable alternate options to Cymbalta for despair or different circumstances. Since each drug has distinctive traits, advantages, dangers, and unintended effects, exploring every choice and checking with a healthcare supplier is significant earlier than switching from Cymbalta.

1. Lexapro 

Lexapro (escitalopram) is an alternative choice to Cymbalta that may be good for people who find themselves involved about Cymbalta’s results when used long-term. Lexapro is within the class of medicine referred to as selective serotonin reuptake inhibitors (SSRIs), which work by rising serotonin ranges within the mind to reinforce temper. There are various features to contemplate when taking a look at Cymbalta vs Lexapro.

Variations between Cymbalta and Lexapro: 

  • Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI) whereas Lexapro is a selective serotonin reuptake inhibitor (SSRI).
  • Cymbalta is FDA-approved to deal with extra circumstances than Lexapro.
  • There may be fewer antagonistic unintended effects of Lexapro than Cymbalta.
  • In some research, Lexapro was more practical in treating main depressive dysfunction (MDD).

Similarities between Cymbalta and Lexapro: 

  • Each can deal with main depressive dysfunction (MDD) and anxiousness
  • Each medicine shouldn’t be used with the rest that will increase serotonin ranges.
  • Cymbalta and Lexapro shouldn’t be used with NSAIDs or different medicine that may trigger bleeding.

2.Effexor (venlafaxine)

Effexor may be a superb choice to discover because it’s one of many medicine just like Cymbalta. As a result of they’re in the identical class of antidepressants — SNRIs — they work equally.

Nevertheless, it’s essential to notice that Effexor could trigger vital blood strain adjustments in comparison with different antidepressants. So, monitoring your BP repeatedly and consulting a medical skilled when taking this drug is essential. 

Variations between Cymbalta and Effexor: 

  • Cymbalta is used to deal with extra medical circumstances.
  • Effexor will be an choice to deal with panic dysfunction and social anxiousness dysfunction.
  • Effexor is extra more likely to lower intercourse drive as a facet impact.
  • Cymbalta is stronger and can be utilized in decrease doses.

Similarities between Cymbalta and Effexor: 

  • Cymbalta and Effexor are each SNRIs.
  • Each medicine can deal with MDD and generalized anxiousness dysfunction (GAD).
  • Shared unintended effects embody dry mouth, drowsiness, lack of urge for food, and nausea.
  • Neither drug ought to be used along with monoamine oxidase inhibitors (MAOIs).

3. Prozac (fluoxetine)

Prozac is a typical and fashionable antidepressant treatment within the SSRI class of medicine. It’s prescribed to deal with main depressive dysfunction and obsessive-compulsive dysfunction. It’s additionally accredited to deal with the consuming dysfunction bulimia and panic dysfunction in adults.

Variations between Cymbalta and Prozac:

  • They’re in numerous courses of medicine — Cymbalta is an SNRI and Prozac is an SSRI.
  • Prozac is accredited to deal with extra psychological well being circumstances.
  • Prozac can be utilized to deal with some disordered consuming circumstances.
  • Cymbalta is accredited to deal with ache associated to some medical circumstances, whereas Prozac isn’t.

Similarities between Cymbalta and Prozac:

  • Cymbalta and Prozac can be utilized to deal with main depressive dysfunction.
  • Research recommend that each medicine have related efficacy and security outcomes.

4. Wellbutrin (bupropion)

Wellbutrin is an antidepressant accredited to deal with main depressive dysfunction (MDD) and seasonal affective dysfunction (SAD). It’s additionally prescribed for smoking cessation. Within the norepinephrine and dopamine reuptake inhibitors (NDRIs) class of medicine, Wellbutrin has a number of the identical antagonistic results as Cymbalta, together with the potential to trigger dry mouth, dizziness, issue sleeping or insomnia, and nausea. 

Variations between Cymbalta and Wellbutrin:

  • Cymbalta and Wellbutrin belong to totally different courses of medicine.
  • Cymbalta may cause diarrhea and fatigue; Wellbutrin usually doesn’t.
  • Wellbutrin may be a greater choice for individuals who expertise weight achieve on Cymbalta.

Similarities between Cymbalta and Wellbutrin:

  • Each medicine are used to deal with sure kinds of ache.
  • Each Cymbalta and Wellbutrin will be efficient in treating despair.
Drug Class of Medicine Treatable Situations Widespread Aspect Results
Cymbalta (duloxetine) SNRI Main depressive dysfunction
Normal anxiousness dysfunction
Nerve ache attributable to diabetes
Power muscle and joint ache
Fibromyalgia
Drowsiness
Constipation
Nausea
Dry mouth
Lack of urge for food
Elevated sweating
Lexapro (escitalopram) SSRI Main depressive dysfunction
Generalized anxiousness dysfunction
Dry mouth
Nausea
Issue sleeping
Confusion
Diarrhea or constipation
Headache
Sexual dysfunction
Dizziness or drowsiness
Effexor (venlafaxine) SNRI Despair
Generalized anxiousness dysfunction
Panic dysfunction
Social anxiousness dysfunction
Nausea
Dry mouth 
Dizziness 
Drowsiness
Constipation
Lack of urge for food
Blurred imaginative and prescient
Prozac (fluoxetine) SSRI Main depressive dysfunction
Obsessive-
compulsive dysfunction
Bulimia
Panic dysfunction
Bipolar despair
Nausea
Dizziness
Drowsiness
Lack of urge for food
Issue sleeping
sweating
Wellbutrin (bupropion) NDRIs Despair
Seasonal have an effect on dysfunction
Smoking cessation
Headache
Sweating
Sleep points
Dry mouth
Dizziness

Pure Alternate options to Cymbalta

Medicines like Cymbalta can work nicely for some individuals, however others would possibly desire a pure different. Whether or not it’s to keep away from unintended effects or since you choose a holistic method, there are a number of non-pharmaceutical Cymbalta alternate options obtainable.

6. Omega-3 fatty acids

Omega-3 fatty acids are identified for coronary heart well being advantages and the power to assist psychological well being. Omega-3s are essential to mind perform and efficiency, and a few analysis has proven they will cut back signs of despair. Omega-3s are discovered naturally in meals sources like salmon or they’re obtainable as dietary supplements.

7. Vitamin D

Generally known as the sunshine vitamin, Vitamin D can increase temper, which could make it a possible different to Cymbalta for despair. Research have discovered that individuals with despair usually have low vitamin D ranges, so supplementing would possibly assist.

8. L-theanine

L-theanine is a singular amino acid present in inexperienced tea leaves. It’s gained reputation lately on account of the calming impact it may well have on the physique and thoughts. In analysis, l-theanine has been proven to be efficient in stress reduction, temper enhancement, and improved sleep high quality.

9. Way of life adjustments 

Adjusting your life-style by specializing in wholesome habits generally is a stunning different to Cymbalta that many individuals may not contemplate. Implement the next into your days to see should you discover a discount in depressive signs and anxiousness.

  • Work out repeatedly: Analysis reveals that getting the center fee up releases endorphins, often known as the feel-good hormones. Even one thing so simple as strolling briskly day by day can enhance your temper.
  • Eat wholesome: Attempt to eat a balanced food regimen stuffed with nutrient-rich meals. It could not remedy your despair, however it may well assist naturally raise your temper.
  • Apply mindfulness: Aware actions like meditation and journaling can change your mindset and enhance your temper.
  • Search remedy: Numerous research have confirmed the improved efficacy of mixing remedy and drugs vs. utilizing one or the opposite alone.

“Remedy is an effective way to develop perception into signs and analysis. It helps to facilitate consciousness and understanding of the problems that the particular person is dealing with. It’s also possible to study well being coping methods to assist handle signs. Typically treatment and remedy are mixed to deal with the particular person and have a optimistic end result.”

Talkspace therapist Bisma Anwar, LPC, LMHC

Concerns for Switching to a Cymbalta Various

Should you’re contemplating switching from a drugs like Cymbalta to a unique drug or a holistic remedy plan, there are a number of essential elements to recollect. Discovering an appropriate different is just potential if it matches your distinctive wants and targets for enchancment.

Contemplate the next:

  • Why do you need to transition from Cymbalta?
  • Do the unintended effects of the drug outweigh any optimistic outcomes?
  • Have you ever talked to your physician about different drugs you’re at present taking?

“You will need to work carefully together with your psychiatrist when switching drugs to keep away from Cymbalta withdrawal. Focus on and be open about your signs and considerations together with your suppliers so they’re conscious of how you might be doing.”

Talkspace therapist Bisma Anwar, LPC, LMHC

Discover the Proper Various with Talkspace 

Should you’re attempting to determine whether or not to alter drugs or take a holistic method to your remedy plan — or should you’re inquisitive about combining drugs with remedy or non-pharmaceutical remedy choices — Talkspace is right here. 

Talkspace is an internet platform with a group of psychological well being professionals who can present remedy, prescriptions, and drugs administration.

We provide telehealth from the consolation of your private home as you make essential choices about your treatment and remedy plan. Our group is right here that will help you navigate the complexities of treatment adjustments.

Sources:

  1. Khan A, Bose A, Alexopoulos GS, Gommoll C, Li D, Gandhi C. Double-blind comparability of Escitalopram and duloxetine in??the??acute remedy of main??depressive dysfunction. Scientific Drug Investigation. 2007;27(7):481-492. doi:10.2165/00044011-200727070-00005. https://pubmed.ncbi.nlm.nih.gov/17563128/. Accessed September 24, 2023.  
  2. Kıvrak Y, Güvenç TS, Akbulut N, et al. Accelerated hypertension after venlafaxine utilization. Case Studies in Psychiatry. 2014;2014:1-4. doi:10.1155/2014/659715. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190979/. Accessed September 24, 2023. 
  3. Eckert L, Lançon C. Duloxetine in contrast with fluoxetine and venlafaxine: Use of meta-regression evaluation for oblique comparisons. BMC Psychiatry. 2006;6(1). doi:10.1186/1471-244x-6-30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1552056/. Accessed September 24, 2023.  
  4. Larrieu T, Layé S. Meals for temper: Relevance of dietary omega-3 fatty acids for despair and anxiousness. Frontiers in Physiology. 2018;9. doi:10.3389/fphys.2018.01047. https://www.frontiersin.org/articles/10.3389/fphys.2018.01047/full. Accessed September 24, 2023. 
  5. BIČÍKOVÁ M, DUŠKOVÁ M, VÍTKŮ J, et al. Vitamin D in anxiousness and affective problems. Physiological Analysis. Printed on-line 2015. doi:10.33549/physiolres.933082.https://www.biomed.cas.cz/physiolres/pdf/64percent20Supplpercent202/64_S101.pdf. Accessed September 24, 2023.
  6. White D, de Klerk S, Woods W, Gondalia S, Noonan C, Scholey A. Anti-stress, behavioural and magnetoencephalography results of an L-theanine-based nutrient drink: A randomised, double-blind, placebo-controlled, crossover trial. Vitamins. 2016;8(1):53. doi:10.3390/nu8010053. https://www.mdpi.com/2072-6643/8/1/53. Accessed September 24, 2023.
  7. Basso JC, Suzuki WA. The results of acute train on temper, cognition, neurophysiology, and neurochemical pathways: A Evaluate. Mind Plasticity. 2017;2(2):127-152. doi:10.3233/bpl-160040. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928534/. Accessed September 24, 2023.
  8. How do I select between treatment and remedy? American Psychological Affiliation. 2017. Accessed September 24, 2023. https://www.apa.org/ptsd-guideline/patients-and-families/medication-or-therapy

Talkspace articles are written by skilled psychological health-wellness contributors; they’re grounded in scientific analysis and evidence-based practices. Articles are extensively reviewed by our group of scientific consultants (therapists and psychiatrists of varied specialties) to make sure content material is correct and on par with present trade requirements.

Our objective at Talkspace is to supply essentially the most up-to-date, helpful, and goal data on psychological health-related matters with the intention to assist readers make knowledgeable choices.

Articles include trusted third-party sources which are both instantly linked to within the textual content or listed on the backside to take readers on to the supply.

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